| Institut Européen de Chimie et Biologie
Research of the Laboratory of Molecular Imaging and Nano-Bio-Technology at the Institut Européen de
Chimie et Biologie focuses on structure-function studies of complexes between proteins and membranes.
The structure and mechanism of assembly of biological macromolecules is determined, at nanometer resolution,
by Cryo-Electron Microscopy, Cryo-Electron Crystallography of 2D crystals and Atomic Force Microscopy.
Quantitative analysis of protein-membrane interactions on solid supports is obtained by QCM-D
(quartz crystal microbalance with dissipation monitoring). Research in Nanotechnology concerns the development of bio-compatible surfaces based on 2D matrices of proteins deposited on solid-supported lipid bilayers.
Key references
1. G. T. Oostergetel, W. Keegstra and A. Brisson (2001), J Mol Biol 314, 245-52.
2. I. Reviakine and A. Brisson (2001), Langmuir 17, 8293-8299.
3. F. Oling, J. S. Santos, N. Govorukhina, C. Mazères-Dubut, W. Bergsma-Schutter, G. Oostergetel,
W. Keegstra, O. Lambert, A. Lewit-Bentley and A. Brisson (2000), J Mol Biol 304, 561-73.
4. I. Reviakine and A. Brisson (2000), Langmuir 16, 1806-1815.
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